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KMID : 0882420110810040533
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Korean Journal of Medicine
2011 Volume.81 No. 4 p.533 ~ p.536
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Systemic Lupus Erythematosus Preceded by Distal Renal Tubular Acidosis
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Kang Jin-Young
Kang Jong-Wan
Kim Ji-Hun
Jin Mi-Kyung
Lim Churl-Hyun
Nam Eon-Jeong
Kang Young-Mo
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Abstract
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Distal renal tubular acidosis (RTA) is characterized by a decreased net H+ secretion in the collecting tubules, which results in a failure of urine acidification and results in metabolic acidosis, hypokalemia, and nephrocalcinosis. The acquired form of distal RTA is associated with tubulointerstitial involvement of immune-mediated disorders such as Sjogren’s syndrome and systemic lupus erythematosus (SLE). Only a few case reports have indicated that distal RTA precedes SLE by months to years. We present a 39-year-old woman who had manifestations of distal RTA for 21 years before the development of overt symptoms of SLE.
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KEYWORD
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Lupus Erythematosus, Systemic, Acidosis, Renal Tubular, Tubulointestitial nephritis
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